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Differences in the indoor concentrations in vari- ous countries are mainly attributable to differences in the type of fuel used for cooking and heating and the rate of fuel consumption. The relation between infant indoor environment and subsequent asthma: a prospective cohort study. Indoor air quality guidelines for trichloroethylene. Other older studies, many coming out of the Second World War, have not been included in published reviews by this author. Personal nitrogen dioxide was higher in women if they cooked more frequently, but only among those who did not ventilate their kitchen by the use of an extrac- tor fan. Prokaryotes are represented by two separate domains-bacteria and archaea. The cytotoxicity associated with naphthalene exposure may play an important role in the overall effects observed in the chronic bioassay. PCE is reasonably anticipated to be a human carcinogen on the basis of lim- ited evidence from studies in humans and sufficient evidence of carcinogenicity from studies in experimental animals. Concordance across species in the reproductive and developmental toxicity of tetrachloroethylene. Eczema was not included except if retrieved in the above-mentioned searches. TCVG causes much more lactate dehydrogenase to be released from male than from female rat kidney cells. NationalResearchCouncil.Healthrisksofradonandotherinternally deposited alpha-emitters. In children in various developing countries, a number of markers for cytotoxic and oxidative stress have been positively correlated with either monitored personal PAH concentration or carcinogenic PAH levels in whole blood.
Organism - Wikipedia. Liver and kidney effects The evidence of an association between PCE exposure and effects on the liver is suggestive.
: TCBunny Black 3D …. Childhood respiratory illness and the home environment. The range and distribution of indoor radon levels in many countries have been determined both by national surveys and in other investigations. study, the ef- fect was selective at the myeloid progenitor line. Polycyclic aromatic hydrocarbons in natural water: sources, occurrence and analysis. Outdoor benzene concentrations are mainly due to traf- fic sources and are affected by season and meteorology. It was found that carbon-monox- ide-poisoned rats displayed impaired maze-learning that did not occur in similar rats made immunologically tolerant to MBP. Many definitions exclude viruses and possible man-made non-organic life forms, as viruses are dependent on the biochemical machinery of a host cell for reproduction. Differences in naphthalene-induced toxicity in the mouse and rat. Effect of low level carbon monoxide exposure on onset and duration of angina pectoris, a study in ten patients with ischemic heart disease. Nitrogen dioxide exposure in vivo and human alveolar macrophage inactivation of influenza virus in vitro. Outside the respiratory tract, the kidney is the organ most exposed to radon decay products. It has been shown that when formaldehyde is mixed with particles, more of it is retained by the respiratory tract than when it is inhaled alone. This decision is disputed by many and is not supported by any convincing body of experimental evidence. . Irritation and odor from formaldehyde: chamber studies. Residential exposure to volatile organic compounds and asthma. Human exposure to tetrachloroethylene: inhalation and skin contact. The difference from members of Group B was very large and signifi- cant over the entire age range of the two groups. The commuters’ exposure to volatile chemicals and carcinogenic risk in Mexico City. The increase in symptom score and the decre- ments in peak flow experienced during the laboratory-confirmed viral infection were larger in children who had higher exposures measured in the week prior to the start of the exacerbation. Associations between personal exposures and fixed-site ambient measurements of fine particulate matter, nitrogen dioxide, and carbon monoxide in Toronto, Canada. Another consideration in the angina data is the fact that COHb was not extended to higher levels as it was for normal sub- jects. study suggests an effect on all pro- genitor cells that results in decreased production of lymphocytes, granulocytes, platelets and red blood cells. Third, and related to the previous point, the group selected for compari- son should ideally comprise a group that uses electricity. National field survey on volatile organic compounds in residential environment. Biological mechanisms Formaldehyde is a normal component of the blood. DCVC gave a negative response at the lower dose level. These indoor levels are likely to be a reflection of the contribution of outdoor sources through infiltration, as the outdoor levels were much higher than in Helsinki, Basel and Oxford. The relative importance of each activation pathway of metabolism depends on several factors, including the tissue level and stabil- ity of each activated form and the levels of expression of the activation and de- toxification enzymes. Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene.
Caffeine - Wikipedia. Characterization of the effects of inhaled perchloroethylene on sustained attention in rats performing a visual signal detection task. Indoor sources Benzene in indoor air can originate from outdoor air and also from sources in- doors such as building materials and furniture, attached garages, heating and cooking systems, stored solvents and various human activities. Also, shops, offices or homes that share a building with a dry cleaning establishment have been found to have higher levels of PCE than those that are not near dry cleaners. Effects of trichloroethylene and perchloroethylene on muscle contractile responses and epithelial prostaglandin release and acetylcholinesterase activity in swine trachea. [Preliminary analysis of indoor pollution from nitrogen dioxide in an area of Northern Italy]. Огнетушитель Ярпожинвест ОП-4(з) ОГН-ОП4. Many studies have been completed in animals and to some extent in humans to determine the metabolism of benzene and its toxicokinetics. Carbon monoxide poisoning while using a small cooking stove in a tent. Nitrogen dioxide is not associated with respiratory infection during the first year of life. The authors felt the lack of a dose–response effect suggested that nitrogen dioxide did not cause these effects, and that the effect size was too small to be of clinical significance. Upper respiratory tract uptake of naphthalene. Complete necropsy was per- formed on each animal.
Robert Maynard and Bernd Seifert chaired the meeting. While the target organs for toxicity in general are similar for different species, this is not the case for carcinogenicity. Muconaldehyde, a potential toxic intermediate of benzene metabolism. Influence of exposure patterns of nitrogen dioxide and modifications by ozone on susceptibility to bacterial infectious disease in mice. Lung cancer Occupational exposure to complex mixtures containing PAHs has been strongly associated with lung cancer. All experts were requested to disclose any circum- stances that could give rise to a potential conflict of interests, i.e. Hematological changes among Chinese workers with a broad range of benzene exposures. Effects of carbon monoxide on myocardial ischemia. These modest results were attributed to nanotube/matrix debonding and crack deflection. Nitrogen dioxide exposure enhances asthmatic reaction to inhaled allergen in subjects with asthma. A prospective study of the association between home gas appliance use during infancy and subsequent dust mite sensitisation and lung function in childhood. Amphetamines and caffeine are stimulants that increase alertness, improve focus, decrease reaction time, and delay fatigue, allowing for an increased intensity and duration of training . This would potentially permit calculation of tissue dose for non-hypoxic tissue effects when the dosimetry models are devel- oped. Committee on the Medical Effects of Air Pollutants. One of the few studies in developed countries to examine the association of bottled gas com- pared to mains gas on respiratory health in adults was conducted in Italy, where cooking with gas is almost universal. Evidence for common descent may be found in traits shared between all living organisms. Winkler-HeilRetal.Comparisonofradonlungdosimetrymodelsforthe estimation of dose uncertainties. A cohort study of cancer among benzene-exposed workers in China: overall results. Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone. Indoor air quality in homes of patients with chronic obstructive pulmonary disease. A potential route of proximate carcinogen metabolism. The edited text was then reviewed by the WHO Guidelines Review Commit- tee. Numerous studies conducted by Aksoy have described haematotoxicity. The chemicals reviewed in this volume are common indoor air pollutants in all regions of the world. Personal exposure to nitrogen dioxide and its association with respiratory illness in Hong Kong. The relation between respiratory illness in infants and gas cooking in the UK: a preliminary report. The ERR/WLM was modified by time since exposure, attained age and exposure rate, but not by duration of exposure. Health damage resulting from chronic, lower-level exposure has been diffi- cult to fully explain on the basis of hypoxia, hypoxaemia and measured COHb, since various physiological mechanisms should quickly compensate. Health statistics review: cancer and birth outcome analysis, Endicott Area, Town of Union, Broome County, New York. Time-course of hemoglobin, heart weight and lactate dehydrogenase isozyme changes. Mitchell, Diane C.; Knight, Carol A.; Hockenberry, Jon; Teplansky, Robyn; Hartman, Terryl J. Dose–response modeling of occupational exposure to polycyclic aromatic hydrocarbons with biomarkers of exposure and effect. Central role of radical cations in metabolic activation of polycyclic hydrocarbons. A similar strategy was followed for a review of the health effects of chronic exposure. Thyagarajan MS, Gunawardena WJ, Coutinho CMA. Formation and persistence of novel benzo[a]pyrene adducts in rat lung, liver, and peripheral blood lymphocyte DNA. BijwaardH,BrugmansMJ,LeenhoutsH.Aconsistenttwo-mutationmodel of lung cancer for different data sets of radon-exposed rats. b Adjusting for year-to-year random variability in indoor radon concentration. A linear correlation has been reported between the inhalation exposure of TCE and the urinary levels of trichloroethanol and trichloroacetic acid. Irritant and adjuvant effects of gaseous formaldehyde on the ovalbumin-induced hyperresponsiveness and inflammation in a rat model. There was no apparent difference in the proportion- ate increase in risk by sex or smoking history, although there was some evidence of decreasing radon-associated lung cancer risk with age. Therefore, new buildings or recently redecorated indoor environments have been associated with high concentrations of benzene from materials and furniture. Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment. Kelly General description There are seven oxides of nitrogen that may be found in the ambient air. In order to overcome this limitation, ceramic-matrix nanocomposites have been receiving attention, primarily due to the significant enhancement on mechanical properties which can be achieved. Polycyclic aromatic hydrocarbons inside and outside of apartments in an urban area. This is the guideline for PAH in indoor air. Indoor risk factors for asthma in a prospective study of adolescents. PBTK modeling demonstrates contribution of dermal and inhalation exposure components to end-exhaled breath concentrations of naphthalene. Smoking as a confounder in ecologic correlations of cancer mortality rates with average county radon levels. Comparison of analytical techniques for the determination of aldehydes in test chambers. Aromatic hydrocarbons in the atmospheric environment. Quantitative PET scan findings in carbon monoxide poisoning. Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: report of three cases. The fracture strength, as an example, is noticeably higher because of the higher interfacial interaction between the particles in nanocomposites. Indoor air quality in smoking and non smoking households. MarshJWetal.Dosimetricmodelsusedinthealpha-riskprojectto quantify exposure of uranium miners to radon gas and its progeny. That people are exposed to air pollutants both outdoors and indoors is obvi- ous. Evaluation of the health impact of lowering the formaldehyde occupational exposure limit for Quebec workers. The mutagenic hazards of settled house dust: a review. An interaction between maternal age and TCE exposure in increasing congenital heart defects has been observed by Yauck et al. Both MMNC and CMNC with CNT nanocomposites hold promise, but also pose challenges for real success. Trichloroethylene metabolism in the rat ovary reduces oocyte fertilizability. Chronic carbon monoxide poisoning, In: Penney DG, ed. The regulations for indoor air pollution in Japan: a public health perspective. These analyses were extensively adjusted for other household and sociodemo- graphic factors. His wife has significant stock in a commercial entity with an interest in air quality